The Christian-Albrechts-University of Kiel (CAU) is one of the leading universities in Germany with the main research topic "Clinical Neuroscience" in the Medical Faculty. The Medical Faculty of the CAU provides all necessary facilities for successful research in neuroscience including the Research Unit for NeuroImaging, the Center for Computational Science, the Center for Human Genetics and the Center for Clinical Trials (ZKS).
The University Hospital of Schleswig-Holstein (UKSH) is the largest clinical center in Northern Germany. Because the UKSH is the only clinical center with a Department of Neuropediatrics in Schleswig-Holstein and has the largest Department of Neurology in Northern Germany, it provides all facilities for diagnosis and treatment of pediatric chronic neuropsychiatric disorders and for successful research with CPND because of excellent recruitment possibilities and technical as well as organizational infrastructure necessary for clinical and experimental research. Brain stimulation has a long tradition at the UKSH and has been studied extensively in different departments such as the Departments of Neurology, Psychiatry, Neuropediatrics and Physiology.
Four departments of the Christian-Albrechts-Universität zu Kiel are involved in the project:
- The Institute of Medical Psychology and Medical Sociology (IMPS)
- The Institute of Medical Informatics and Statistics (IMIS)
- The Kiel Center for Clinical Trials (ZKS)
- The Section of Medical Ethics at the Institute of Experimental Medicine
The Institute of Medical Psychology and Medical Sociology (IMPS) is a scientific and clinical institution connected to both the CAU and UKSH. The Institute has a lot of experience in performing studies on transcranial electrical stimulation in children and adolescents. The IMPS has finished a number of studies on tDCS and tACS in different age groups of young subjects and in patients with ADHD and migraine. The IMPS also has its own outpatient department with the main clinical focus being on care for children and adolescents with ADHD and autism. Annually, about 30 patients with ASD and 100 patients with ADHD are diagnosed and treated at the IMPS. Moreover, the IMPS supervises the clinical work in the University Hospital of Pediatric Neurology as well as in the Social Pediatric Center (SPZ) and is part of the autism and ADHD networks in Schleswig-Holstein.
Role of IMPS in STIPED
The IMPS leads work package 1 (management of STIPED) and contributes to the work packages 3, 4 and 5 (data collection and analysis). In work package 3 a tDCS study in healthy children and adolescents will be conducted and in work package 4 a home-based individualized tDCS study in patients with ADHD will be carried out. The IMPS also contributes to work package 10 (dissemination, exploitation and communication).
STIPED team at IMPS
Prof. Dr. Michael Siniatchkin
Director of the Institute of Medical Psychology and Medical Sociology
Prof. Siniatchkin is the coordinator of STIPED. He is the director of the IMPS and has a long-lasting experience in clinical trials, studies on transcranial stimulation (tDCS, TMS), multimodal neuroimaging (EEG, MEG, fMRI) and advance data analysis (source and connectivity analysis).
Phone: +49 431 500 30 801
Dipl.-Psych. Karolin Waschull
Dr. Vera Moliadze
Leader of clinical study 1
Head of the neurophysiological laboratory and leader of the transcranial brain stimulation group
Phone: + 49 431 500 30835
Dipl.-Psych. Maike Splittgerber
Phone: + 49 431 500 30812
Research activities of the Institute of Medical Statistics and Informatics (IMIS) are focused upon medical statistics and genetic epidemiology. Scientists at IMIS contribute to numerous projects in molecular and clinical medical research networks and pursue own methodological developments. Further responsibilities of IMIS as a scientific institute encompass teaching and consulting in all aspects of the application and development of biometrical and epidemiological methods. The IMIS is fully equipped to undertake all necessary biometric analyses.
The Kiel Center for Clinical Trials (ZKS) is a research support unit maintained by the Medical Faculty of the CAU and adjunct to IMIS. ZKS Kiel is offering its services primarily to academic researchers undertaking clinical studies with medicinal products, medical devices, or other studies involving human subjects. The ZKS Kiel provides support at all major stages of clinical trials, ranging from protocol development and biometrics to regulatory affairs, data management and quality assurance. The ZKS Kiel is working with validated hardware and software, back-up systems to allow the conduct of data management in clinical trials in accordance all pending legal regulations.
Role of IMIS and ZKS in STIPED
IMIS and ZKS will lead the work package 9 "Statistics and data management" and will thus substantially contribute to the planning (protocol development) and conduct (randomization, data management, monitoring for German trial sites, statistical analysis, publications) of the randomized double-blind sham-controlled trials within STIPED and will provide statistical support to all of the project partners.
STIPED team at IMIS and ZKS
The Section of Medical Ethics at the Institute of Experimental Medicine, CAU Kiel, works on the ethical, theoretical, social, and regulatory implications of modern biomedicine and health care, seeking to produce innovative research results and open up public debate. It covers a broad range of topics in the field of ethics and philosophy of medicine, ranging from theoretical analysis, to mixed methods research projects, as well as policy development and practical ethical advice at the hospital bed.
Role of the Section of Medical Ethics in STIPED
The Section of Medical Ethics at the Institute of Experimental Medicine leads work package 2 "Ethical and social issues, patient and public involvement". This WP advises on all research ethics issues within STIPED, investigates beliefs and attitudes towards application of tDCS techniques in children and adolescents and examines and addresses concerns and expectations, maps and addresses ethical issues of tDCS as treatment and as nonpharmacological neuroenhancement, and develops recommendations and policy suggestions for tDCS in pediatrics.